Wednesday, May 9, 2012

Wegener granulomatosis

Upper resp disease + lower resp disease, + glomerulonephritis
Other signs of vasculitis on skin,eyes, joints etc

Best initial: c-ANCA
most accurate test: biopsy
(lung biopsy best)

Tmt: Prednisone +cyclophosphamide.



note: Good pasture has similar presentation but no upper resp involvement and anti GBM abs r present (Best initial test).
kidney biopsy shows linear deposits. No signs of systemic vasculitis unlike in Wegener's granulomatosis.

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