Alzheimers : memory loss first before onset of behavioural changes, confusion, gets lost in familiar neighbourhood , neurofibrillary tangles, enlarged ventricles, (Drug Tmt: Donepezil)
Lewy body : Parkinsonism, Hallucinations, fluctuations in cognition and alertness
Picks dx : behavioural changes more prominent and preceeds memory loss, aphasia, frontotemporal atrophy
Pseudodementia : Depression
Normal pressure hydroceph : urinary incontinence, gait ataxia (large vol LP is both diagnostic and therapeutic)
Creutzfeldt Jacob dx : prion dx, rapidly progressing dementia, ataxia, myoclonus, gait abnormalities, seizures, memory loss, personality changes, hallucination, sharp triphasic synchronous discharge on EEG. Mostly sporadic.
Huntington : Early onset dementia, Ataxia, Chorea, Family history, Aut Dominant.