Anarsaca
periorbital edema
hypoalbuminemia
hyperlipidemia
hyperproteinuria >3.5g/day,
hypertension
Thrombosis (due to loss of protein c & s and antithrombin)
Infections (Ig loss)
Initial test : Urinalysis
Most accurate for cause : Biopsy
Most accurate measure of proteinuria: Urine albumin/creatinine ratio = 24hrs urinary protein
Children : think minimal change dx
Adults : most common is focal segmental (initially membranous glomerulonephritis)
AIDS: think focal segmental
Renal Biopy done in Adults
Biopsy not reqd in children with suspected NS, treat empirically with prednisone. + cyclophosphamide if resistant
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