Friday, April 27, 2012

Nephrotic Syndrome

periorbital edema
hyperproteinuria >3.5g/day,
Thrombosis (due to loss of protein c  & s and antithrombin)
Infections (Ig loss)

Initial test : Urinalysis
Most accurate for cause : Biopsy
Most accurate measure of proteinuria: Urine albumin/creatinine ratio = 24hrs urinary protein

Children : think minimal change dx
Adults : most common is focal segmental (initially membranous glomerulonephritis)
AIDS: think focal segmental

Renal Biopy done in Adults
Biopsy not reqd in children with suspected NS, treat empirically with prednisone. + cyclophosphamide if resistant

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