Thursday, May 10, 2012

Primary biliary cirrhosis

interlobular bile duct destruction

itchy, yellow, middle aged woman with high alkaline phosphatase, normal transaminases, high GGT, high bilirubin and positive Anti mitochondrial antibodies, ANA

+signs of cirrhosis
Liver biopsy shows periductal mononuclear infilterate with bile duct destruction

Tmt: Ursodeoxycholic acid, cholestyramine (reduces itching)

no cure

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