Thursday, May 17, 2012

TTP or HUS?

Both are microangiopathic hemolytic anemias
Both present with
  1. Thrombocytopenia
  2. hemolytic anemia (low hct, schistocytes, unconjugated hyperbilirubinemia, high LDH etc)
  3. Acute renal insufficiency (high BUN)
  4. Fever
  5. Altered mental status
To differentiate however,

Altered mental status is more prominent in TTP
Acute anuric renal failure is more prominent in HUS

less specific is that HUS more in children while TTP more in adults

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