Wednesday, May 16, 2012

Selective Estrogen Receptor Modulators

Clomifene: @ hypothalamus: antagonist

Raloxifene:                              @breast :antagonist   @bone: agonist   @uterus: antagonist

Tamoxifene:                            @breast :antagonist   @bone: agonist   @uterus: agonist

Others include: femarelle, toremifene etc.

All reduce risk of breast cancer
All reduce risk of postmenopausal osteoporosis
Tamoxifene increases risk of endometrial cancer
SERMs increase risk of DVT

Clomifene used for treatment of infertility(anovulation)
Raloxifene used for treatment of Osteoporosis and breast cancer
Tamoxifene used for treatment of breast cancer

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