TTP or HUS?

Both are microangiopathic hemolytic anemias
Both present with

1. Thrombocytopenia
2. hemolytic anemia (low hct, schistocytes, unconjugated hyperbilirubinemia, high LDH etc)
3. Acute renal insufficiency (high BUN)
4. Fever
5. Altered mental status

To differentiate however,

Altered mental status is more prominent in TTP
Acute anuric renal failure is more prominent in HUS

less specific is that HUS more in children while TTP more in adults

Fanconi anemia

Autosomal recessive

Aplastic anemia


Pancytopenia

Hyperpigmentation

Short stature

microcephaly

hypogonadism

upper limb anomalies

radswiki.net

Cure is BM transplant

ITP or TTP?

Immune Thrombocytopenic Purpura:
Isolated thrombocytopenia, no hemolysis, normal red cell morphology
Tmt: first line is steroids


Thrombotic Thrombocytopenic purpura:
Microangiopathy due to narrowing of small vessels by thrombus
Thrombocytopenia, fragmented rbcs, schistocytes, neurological symptoms.
Tmt: plasmapheresis